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Frequently Asked Questions

What is evidence level?

Evidence level of an entry in HTP database can be the following:

3D structure
3D structure of the transmembrane protein was determined by X-ray diffraction, by electron diffraction or by NMR.
In this case a CrossRef to the appropriate PDBTM entry(ies) is(are) given.
Experiment
There is(are) experimental result(s) about the topology.
In this case a CrossRef to the appropriate PDB, TOPDB and/or TOPDOM entries should be given.
TOPDOM
There are domains and sequence motifs located conservatively in one side of transmembrane proteins.
Exists
There is evidence to the existence of the protein.
Prediction
There is no evidence to the existence of the protein. Both the amino acid sequence and the topology are predicted from the human genome sequence.