Measuring the reliability of the consensus prediction
Reliability of topology prediction is calculated by summing up the posterior probabilities
along the state path determined by the Viterbi algorithm in the HMMTOP program. The reliability
highly correlates with the prediction accuracy, measured in a human benchmark set, therefore
it can be used to estimate the prediction accuracy of an individual prediction without any
information about the topology at all.
A diagram on the right shows a certain prediction. In that case the sum of the reliability through
the Viterbi path is 97% (red: inside, blue: outside, yellow: trans-membrane).
